50 Years of the steric-blocking mechanism in vertebrate skeletal muscle: a retrospective
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Date
2023-09
Open Access Location
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Springer Nature Switzerland AG
Rights
CC BY 4.0
Abstract
Fifty years have now passed since Parry and Squire proposed a detailed structural model that explained how tropomyosin, mediated by troponin, played a steric-blocking role in the regulation of vertebrate skeletal muscle. In this Special Issue dedicated to the memory of John Squire it is an opportune time to look back on this research and to appreciate John’s key contributions. A review is also presented of a selection of the developments and insights into muscle regulation that have occurred in the years since this proposal was formulated.
Description
Keywords
3-D reconstruction, Actin, HMM S-1, Relaxed and contracting muscle, Tropomyosin, Troponin, X-ray diffraction, Animals, Actins, Retrospective Studies, Troponin, Muscle, Skeletal, Tropomyosin, Vertebrates, Calcium
Citation
Parry DAD. (2023). 50 Years of the steric-blocking mechanism in vertebrate skeletal muscle: a retrospective.. J Muscle Res Cell Motil. 44. 3. (pp. 133-141).