Background: The identification of the vitamin D receptor in the endocrine pancreas suggests a
role for vitamin D in insulin secretion. There is also some limited evidence that vitamin D influences
insulin resistance, and thus the early stages of the development of type 2 diabetes.
Methods: Eighty-four women of South Asian origin, living in Auckland, New Zealand, were
randomised to receive either a supplement (4000IU 25(OH)D3 per day) or a placebo for 6 months.
At baseline, all participants were vitamin D deficient (serum 25(OH)D3 <50 nmol/L), insulin
resistant (HOMA-IR > 1.93) and/or hyperinsulinaemic, hyperglycemic or had clinical signs of
dislipidaemia. Changes in HOMA-IR, lipids, parathyroid hormone, calcium and bone markers were
monitored at 3 months and 6 months.
Discussion: This randomised, controlled trial will be the first to investigate the effect of vitamin
D supplementation on insulin resistance in non-diabetic subjects. It will subsequently contribute to
the growing body of evidence about the role of vitamin D in metabolic syndrome.Registered
Trial registration: Registered clinical trial – Registration No. ACTRN12607000642482
von Hurst, P. R., Stonehouse, W., Matthys, C., Conlon, C., Kruger, M. C., & Coad, J. (2008). Study Protocol-Metabolic syndrome, vitamin D and bone status in South Asian women living in Auckland, New Zealand: A randomised, placebo-controlled, double-blind vitamin D intervention. Bmc Public Health, 8(267). doi: 10.1186/1471-2458-8-267
2008 von Hurst et al; licensee BioMed Central Ltd.
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