Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia.
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Date
2019-03
Open Access Location
Journal Title
Journal ISSN
Volume Title
Publisher
John Wiley and Sons Inc on behalf of The Alzheimer's Association
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Abstract
Introduction
In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia.
Methods
Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models.
Results
In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini–Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E ε4 (1.8 [1.3-2.5]) increased the risk of dementia.
Discussion
SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts.
Description
Keywords
Alzheimer's disease, Dementia Lewy bodies, Dementia incidence, Frontotemporal dementia, Preclinical Alzheimer's disease, Subjective cognitive decline, Vascular dementia, Aged, Aged, 80 and over, Cognitive Dysfunction, Cohort Studies, Dementia, Diagnostic Self Evaluation, Disease Progression, Female, Humans, Incidence, Male, Middle Aged, Risk Factors, Self Concept
Citation
Slot RER, Sikkes SAM, Berkhof J, Brodaty H, Buckley R, Cavedo E, Dardiotis E, Guillo-Benarous F, Hampel H, Kochan NA, Lista S, Luck T, Maruff P, Molinuevo JL, Kornhuber J, Reisberg B, Riedel-Heller SG, Risacher SL, Roehr S, Sachdev PS, Scarmeas N, Scheltens P, Shulman MB, Saykin AJ, Verfaillie SCJ, Visser PJ, Vos SJB, Wagner M, Wolfsgruber S, Jessen F, Alzheimer's Disease Neuroimaging Initiative , DESCRIPA working group , INSIGHT-preAD study group , SCD-I working group , van der Flier WM. (2019). Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia.. Alzheimers Dement. 15. 3. (pp. 465-476).