Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia.

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dc.citation.issue3
dc.citation.volume15
dc.contributor.authorSlot RER
dc.contributor.authorSikkes SAM
dc.contributor.authorBerkhof J
dc.contributor.authorBrodaty H
dc.contributor.authorBuckley R
dc.contributor.authorCavedo E
dc.contributor.authorDardiotis E
dc.contributor.authorGuillo-Benarous F
dc.contributor.authorHampel H
dc.contributor.authorKochan NA
dc.contributor.authorLista S
dc.contributor.authorLuck T
dc.contributor.authorMaruff P
dc.contributor.authorMolinuevo JL
dc.contributor.authorKornhuber J
dc.contributor.authorReisberg B
dc.contributor.authorRiedel-Heller SG
dc.contributor.authorRisacher SL
dc.contributor.authorRoehr S
dc.contributor.authorSachdev PS
dc.contributor.authorScarmeas N
dc.contributor.authorScheltens P
dc.contributor.authorShulman MB
dc.contributor.authorSaykin AJ
dc.contributor.authorVerfaillie SCJ
dc.contributor.authorVisser PJ
dc.contributor.authorVos SJB
dc.contributor.authorWagner M
dc.contributor.authorWolfsgruber S
dc.contributor.authorJessen F
dc.contributor.authorAlzheimer's Disease Neuroimaging Initiative
dc.contributor.authorDESCRIPA working group
dc.contributor.authorINSIGHT-preAD study group
dc.contributor.authorSCD-I working group
dc.contributor.authorvan der Flier WM
dc.coverage.spatialUnited States
dc.date.accessioned2023-11-23T00:49:41Z
dc.date.accessioned2024-07-25T06:41:00Z
dc.date.available2018-12-13
dc.date.available2023-11-23T00:49:41Z
dc.date.available2024-07-25T06:41:00Z
dc.date.issued2019-03
dc.description.abstractIntroduction In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia. Methods Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models. Results In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini–Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E ε4 (1.8 [1.3-2.5]) increased the risk of dementia. Discussion SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts.
dc.format.pagination465-476
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/30555032
dc.identifier.citationSlot RER, Sikkes SAM, Berkhof J, Brodaty H, Buckley R, Cavedo E, Dardiotis E, Guillo-Benarous F, Hampel H, Kochan NA, Lista S, Luck T, Maruff P, Molinuevo JL, Kornhuber J, Reisberg B, Riedel-Heller SG, Risacher SL, Roehr S, Sachdev PS, Scarmeas N, Scheltens P, Shulman MB, Saykin AJ, Verfaillie SCJ, Visser PJ, Vos SJB, Wagner M, Wolfsgruber S, Jessen F, Alzheimer's Disease Neuroimaging Initiative , DESCRIPA working group , INSIGHT-preAD study group , SCD-I working group , van der Flier WM. (2019). Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia.. Alzheimers Dement. 15. 3. (pp. 465-476).
dc.identifier.doi10.1016/j.jalz.2018.10.003
dc.identifier.eissn1552-5279
dc.identifier.elements-typejournal-article
dc.identifier.issn1552-5260
dc.identifier.piiS1552-5260(18)33563-5
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70666
dc.languageeng
dc.publisherJohn Wiley and Sons Inc on behalf of The Alzheimer's Association
dc.relation.isPartOfAlzheimers Dement
dc.subjectAlzheimer's disease
dc.subjectDementia Lewy bodies
dc.subjectDementia incidence
dc.subjectFrontotemporal dementia
dc.subjectPreclinical Alzheimer's disease
dc.subjectSubjective cognitive decline
dc.subjectVascular dementia
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectCognitive Dysfunction
dc.subjectCohort Studies
dc.subjectDementia
dc.subjectDiagnostic Self Evaluation
dc.subjectDisease Progression
dc.subjectFemale
dc.subjectHumans
dc.subjectIncidence
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectRisk Factors
dc.subjectSelf Concept
dc.titleSubjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia.
dc.typeJournal article
pubs.elements-id455039
pubs.organisational-groupOther
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