Identification of candidate novel production variants on the Bos taurus chromosome X

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dc.citation.issue11
dc.citation.volume106
dc.contributor.authorTrebes H
dc.contributor.authorWang Y
dc.contributor.authorReynolds E
dc.contributor.authorTiplady K
dc.contributor.authorHarland C
dc.contributor.authorLopdell T
dc.contributor.authorJohnson T
dc.contributor.authorDavis S
dc.contributor.authorHarris B
dc.contributor.authorSpelman R
dc.contributor.authorCouldrey C
dc.coverage.spatialUnited States
dc.date.accessioned2024-12-04T21:53:53Z
dc.date.available2024-12-04T21:53:53Z
dc.date.issued2023-11
dc.description.abstractChromosome X is often excluded from bovine genetic studies due to complications caused by the sex specific nature of the chromosome. As chromosome X is the second largest cattle chromosome and makes up approximately 6% of the female genome, finding ways to include chromosome X in dairy genetic studies is important. Using female animals and treating chromosome X as an autosome, we performed X chromosome inclusive genome-wide association studies in the selective breeding environment of the New Zealand dairy industry, aiming to identify chromosome X variants associated with milk production traits. We report on the findings of these genome-wide association studies and their potential effect within the dairy industry. We identify missense mutations in the MOSPD1 and CCDC160 genes that are associated with decreased milk volume and protein production and increased fat production. Both of these mutations are exonic SNP that are more prevalent in the Jersey breed than in Holstein-Friesians. Of the 2 candidates proposed it is likely that only one is causal, though we have not been able to identify which is more likely.
dc.description.confidentialfalse
dc.edition.editionNovember 2023
dc.format.pagination7799-7815
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37562645
dc.identifier.citationTrebes H, Wang Y, Reynolds E, Tiplady K, Harland C, Lopdell T, Johnson T, Davis S, Harris B, Spelman R, Couldrey C. (2023). Identification of candidate novel production variants on the Bos taurus chromosome X.. J Dairy Sci. 106. 11. (pp. 7799-7815).
dc.identifier.doi10.3168/jds.2022-23095
dc.identifier.eissn1525-3198
dc.identifier.elements-typejournal-article
dc.identifier.issn0022-0302
dc.identifier.piiS0022-0302(23)00438-1
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/72206
dc.languageeng
dc.publisherElsevier Inc. and Fass Inc. on behalf of the American Dairy Science Association
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S0022030223004381
dc.relation.isPartOfJ Dairy Sci
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectX chromosome
dc.subjectgenome-wide association study
dc.subjectgenomic selection
dc.subjectmilk production
dc.titleIdentification of candidate novel production variants on the Bos taurus chromosome X
dc.typeJournal article
pubs.elements-id480014
pubs.organisational-groupOther
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