Identification of candidate novel production variants on the Bos taurus chromosome X
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Date
2023-11
Open Access Location
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Inc. and Fass Inc. on behalf of the American Dairy Science Association
Rights
(c) 2023 The Author/s
CC BY 4.0
CC BY 4.0
Abstract
Chromosome X is often excluded from bovine genetic studies due to complications caused by the sex specific nature of the chromosome. As chromosome X is the second largest cattle chromosome and makes up approximately 6% of the female genome, finding ways to include chromosome X in dairy genetic studies is important. Using female animals and treating chromosome X as an autosome, we performed X chromosome inclusive genome-wide association studies in the selective breeding environment of the New Zealand dairy industry, aiming to identify chromosome X variants associated with milk production traits. We report on the findings of these genome-wide association studies and their potential effect within the dairy industry. We identify missense mutations in the MOSPD1 and CCDC160 genes that are associated with decreased milk volume and protein production and increased fat production. Both of these mutations are exonic SNP that are more prevalent in the Jersey breed than in Holstein-Friesians. Of the 2 candidates proposed it is likely that only one is causal, though we have not been able to identify which is more likely.
Description
Keywords
X chromosome, genome-wide association study, genomic selection, milk production
Citation
Trebes H, Wang Y, Reynolds E, Tiplady K, Harland C, Lopdell T, Johnson T, Davis S, Harris B, Spelman R, Couldrey C. (2023). Identification of candidate novel production variants on the Bos taurus chromosome X.. J Dairy Sci. 106. 11. (pp. 7799-7815).