Effect of Amino Acid Supplementation on Iron Regulation after Endurance Exercise.
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Date
2023-11-25
Open Access Location
Authors
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Publisher
MDPI (Basel, Switzerland)
Rights
(c) 2023 The Author/s
CC BY 4.0
CC BY 4.0
Abstract
The purpose of this study was to determine the effects of pre-exercise amino acid (AA) supplementation on post-exercise iron regulation. Ten healthy males participated under two different sets of conditions in a randomized, double-blind, crossover design with a washout period of at least 21 days. Participants received either an AA supplement or placebo (PLA) for five consecutive days (4 g/dose, 3 doses/day). On the sixth day, participants ran on a treadmill for 60 min at 70% of maximal oxygen consumption (V˙O2max). Venous blood samples were collected before (baseline), immediately after, and 1 and 3 h after exercise. The serum hepcidin levels increased significantly 3 h post-exercise in both trials when compared to the baseline (p < 0.001), but the levels were not different between trials. The plasma interleukin-6 (IL-6) level significantly increased immediately after exercise compared to the baseline (p < 0.001) and was significantly higher in the AA trial than in the PLA trial (p = 0.014). Moreover, the exercise-induced increase in serum glycerol level was significantly higher in the AA trial (21.20 ± 3.98 mg/L) than in the PLA trial (17.28 ± 4.47 mg/L, p = 0.017). No significant differences were observed between the AA and PLA trials for serum iron, ferritin, and total ketone body levels (p > 0.05). In conclusion, five days of AA supplementation augmented exercise-induced increases in IL-6 and glycerol in healthy males. However, it did not affect post-exercise iron status or regulation.
Description
Keywords
amino acid supplementation, hepcidin, interleukin-6, iron regulation, Male, Humans, Iron, Interleukin-6, Glycerol, Hepcidins, Dietary Supplements, Amino Acids, Polyesters
Citation
Lin C-A, Hayashi N, Badenhorst CE, Goto K. (2023). Effect of Amino Acid Supplementation on Iron Regulation after Endurance Exercise.. Nutrients. 15. 23. (pp. 4924-).