Effect of Amino Acid Supplementation on Iron Regulation after Endurance Exercise.

Simple item page
dc.citation.issue23
dc.citation.volume15
dc.contributor.authorLin C-A
dc.contributor.authorHayashi N
dc.contributor.authorBadenhorst CE
dc.contributor.authorGoto K
dc.contributor.editorRowlands D
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-05-22T01:54:28Z
dc.date.available2024-05-22T01:54:28Z
dc.date.issued2023-11-25
dc.description.abstractThe purpose of this study was to determine the effects of pre-exercise amino acid (AA) supplementation on post-exercise iron regulation. Ten healthy males participated under two different sets of conditions in a randomized, double-blind, crossover design with a washout period of at least 21 days. Participants received either an AA supplement or placebo (PLA) for five consecutive days (4 g/dose, 3 doses/day). On the sixth day, participants ran on a treadmill for 60 min at 70% of maximal oxygen consumption (V˙O2max). Venous blood samples were collected before (baseline), immediately after, and 1 and 3 h after exercise. The serum hepcidin levels increased significantly 3 h post-exercise in both trials when compared to the baseline (p < 0.001), but the levels were not different between trials. The plasma interleukin-6 (IL-6) level significantly increased immediately after exercise compared to the baseline (p < 0.001) and was significantly higher in the AA trial than in the PLA trial (p = 0.014). Moreover, the exercise-induced increase in serum glycerol level was significantly higher in the AA trial (21.20 ± 3.98 mg/L) than in the PLA trial (17.28 ± 4.47 mg/L, p = 0.017). No significant differences were observed between the AA and PLA trials for serum iron, ferritin, and total ketone body levels (p > 0.05). In conclusion, five days of AA supplementation augmented exercise-induced increases in IL-6 and glycerol in healthy males. However, it did not affect post-exercise iron status or regulation.
dc.description.confidentialfalse
dc.edition.editionDecember-1 2023
dc.format.pagination4924-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38068782
dc.identifier.citationLin C-A, Hayashi N, Badenhorst CE, Goto K. (2023). Effect of Amino Acid Supplementation on Iron Regulation after Endurance Exercise.. Nutrients. 15. 23. (pp. 4924-).
dc.identifier.doi10.3390/nu15234924
dc.identifier.eissn2072-6643
dc.identifier.elements-typejournal-article
dc.identifier.issn2072-6643
dc.identifier.number4924
dc.identifier.piinu15234924
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69637
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2072-6643/15/23/4924
dc.relation.isPartOfNutrients
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectamino acid supplementation
dc.subjecthepcidin
dc.subjectinterleukin-6
dc.subjectiron regulation
dc.subjectMale
dc.subjectHumans
dc.subjectIron
dc.subjectInterleukin-6
dc.subjectGlycerol
dc.subjectHepcidins
dc.subjectDietary Supplements
dc.subjectAmino Acids
dc.subjectPolyesters
dc.titleEffect of Amino Acid Supplementation on Iron Regulation after Endurance Exercise.
dc.typeJournal article
pubs.elements-id485269
pubs.organisational-groupCollege of Health
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