Allogeneic mesenchymal stromal cells for cartilage regeneration: A review of in vitro evaluation, clinical experience, and translational opportunities

Simple item page
dc.citation.issue11
dc.citation.volume10
dc.contributor.authorAldrich ED
dc.contributor.authorCui X
dc.contributor.authorMurphy CA
dc.contributor.authorLim KS
dc.contributor.authorHooper GJ
dc.contributor.authorMcIlwraith CW
dc.contributor.authorWoodfield TBF
dc.coverage.spatialEngland
dc.date.accessioned2024-01-29T00:23:02Z
dc.date.accessioned2024-07-25T06:51:33Z
dc.date.available2021-08-13
dc.date.available2024-01-29T00:23:02Z
dc.date.available2024-07-25T06:51:33Z
dc.date.issued2021-11
dc.description.abstractThe paracrine signaling, immunogenic properties and possible applications of mesenchymal stromal cells (MSCs) for cartilage tissue engineering and regenerative medicine therapies have been investigated through numerous in vitro, animal model and clinical studies. The emerging knowledge largely supports the concept of MSCs as signaling and modulatory cells, exerting their influence through trophic and immune mediation rather than as a cell replacement therapy. The virtues of allogeneic cells as a ready-to-use product with well-defined characteristics of cell surface marker expression, proliferative ability, and differentiation capacity are well established. With clinical applications in mind, a greater focus on allogeneic cell sources is evident, and this review summarizes the latest published and upcoming clinical trials focused on cartilage regeneration adopting allogeneic and autologous cell sources. Moreover, we review the current understanding of immune modulatory mechanisms and the role of trophic factors in articular chondrocyte-MSC interactions that offer feasible targets for evaluating MSC activity in vivo within the intra-articular environment. Furthermore, bringing labeling and tracking techniques to the clinical setting, while inherently challenging, will be extremely informative as clinicians and researchers seek to bolster the case for the safety and efficacy of allogeneic MSCs. We therefore review multiple promising approaches for cell tracking and labeling, including both chimerism studies and imaging-based techniques, that have been widely explored in vitro and in animal models. Understanding the distribution and persistence of transplanted MSCs is necessary to fully realize their potential in cartilage regeneration techniques and tissue engineering applications.
dc.description.confidentialfalse
dc.edition.editionNovember 2021
dc.format.pagination1500-1515
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/34387402
dc.identifier.citationAldrich ED, Cui X, Murphy CA, Lim KS, Hooper GJ, McIlwraith CW, Woodfield TBF. (2021). Allogeneic mesenchymal stromal cells for cartilage regeneration: A review of in vitro evaluation, clinical experience, and translational opportunities.. Stem Cells Transl Med. 10. 11. (pp. 1500-1515).
dc.identifier.doi10.1002/sctm.20-0552
dc.identifier.eissn2157-6580
dc.identifier.elements-typejournal-article
dc.identifier.issn2157-6564
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71038
dc.languageeng
dc.publisherWiley Periodicals LLC on behalf of AlphaMed Press
dc.publisher.urihttps://academic.oup.com/stcltm/article/10/11/1500/6517828
dc.relation.isPartOfStem Cells Transl Med
dc.rights(c) 2021 The Author/s
dc.rightsCC BY-NC-ND 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectallogeneic
dc.subjectcartilage regeneration
dc.subjectchondrogenesis
dc.subjectmesenchymal stromal cells
dc.subjecttissue engineering
dc.subjectumbilical cord blood
dc.subjectAnimals
dc.subjectCartilage, Articular
dc.subjectCell Differentiation
dc.subjectChondrogenesis
dc.subjectHematopoietic Stem Cell Transplantation
dc.subjectMesenchymal Stem Cell Transplantation
dc.subjectMesenchymal Stem Cells
dc.subjectTissue Engineering
dc.titleAllogeneic mesenchymal stromal cells for cartilage regeneration: A review of in vitro evaluation, clinical experience, and translational opportunities
dc.typeJournal article
pubs.elements-id448174
pubs.organisational-groupOther
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Published version
Size:
10.86 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles