GCN2 in Viral Defence and the Subversive Tactics Employed by Viruses

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dc.citation.issue13
dc.citation.volume436
dc.contributor.authorGibbs VJ
dc.contributor.authorLin YH
dc.contributor.authorGhuge AA
dc.contributor.authorAnderson RA
dc.contributor.authorSchiemann AH
dc.contributor.authorConaglen L
dc.contributor.authorSansom BJM
dc.contributor.authorda Silva RC
dc.contributor.authorSattlegger E
dc.contributor.editorFreed EO
dc.coverage.spatialNetherlands
dc.date.accessioned2024-07-01T01:59:56Z
dc.date.available2024-07-01T01:59:56Z
dc.date.issued2024-07-01
dc.description.abstractThe recent SARS-CoV-2 pandemic and associated COVID19 disease illustrates the important role of viral defence mechanisms in ensuring survival and recovery of the host or patient. Viruses absolutely depend on the host's protein synthesis machinery to replicate, meaning that impeding translation is a powerful way to counteract viruses. One major approach used by cells to obstruct protein synthesis is to phosphorylate the alpha subunit of eukaryotic translation initiation factor 2 (eIF2α). Mammals possess four different eIF2α-kinases: PKR, HRI, PEK/PERK, and GCN2. While PKR is currently considered the principal eIF2α-kinase involved in viral defence, the other eIF2α-kinases have also been found to play significant roles. Unsurprisingly, viruses have developed mechanisms to counteract the actions of eIF2α-kinases, or even to exploit them to their benefit. While some of these virulence factors are specific to one eIF2α-kinase, such as GCN2, others target all eIF2α-kinases. This review critically evaluates the current knowledge of viral mechanisms targeting the eIF2α-kinase GCN2. A detailed and in-depth understanding of the molecular mechanisms by which viruses evade host defence mechanisms will help to inform the development of powerful anti-viral measures.
dc.description.confidentialfalse
dc.edition.edition1 July 2024
dc.format.pagination168594-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38724002
dc.identifier.citationGibbs VJ, Lin YH, Ghuge AA, Anderson RA, Schiemann AH, Conaglen L, Sansom BJM, da Silva RC, Sattlegger E. (2024). GCN2 in Viral Defence and the Subversive Tactics Employed by Viruses.. J Mol Biol. 436. 13. (pp. 168594-).
dc.identifier.doi10.1016/j.jmb.2024.168594
dc.identifier.eissn1089-8638
dc.identifier.elements-typejournal-article
dc.identifier.issn0022-2836
dc.identifier.number168594
dc.identifier.piiS0022-2836(24)00189-X
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70047
dc.languageeng
dc.publisherElsevier Ltd
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S002228362400189X
dc.relation.isPartOfJ Mol Biol
dc.rights(c) 2024 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectEIF2AK4
dc.subjectGCN2
dc.subjecteIF2α
dc.subjectintegrated stress response
dc.subjectviral virulence factors
dc.subjectHumans
dc.subjectProtein Serine-Threonine Kinases
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectAnimals
dc.subjectEukaryotic Initiation Factor-2
dc.subjectVirus Replication
dc.subjecteIF-2 Kinase
dc.subjectPhosphorylation
dc.subjectHost-Pathogen Interactions
dc.titleGCN2 in Viral Defence and the Subversive Tactics Employed by Viruses
dc.typeJournal article
pubs.elements-id488775
pubs.organisational-groupOther
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