Concentrations of Plasma Amino Acids and Neurotransmitters in Participants with Functional Gut Disorders and Healthy Controls

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dc.citation.issue2
dc.citation.volume13
dc.contributor.authorJames SC
dc.contributor.authorFraser K
dc.contributor.authorCooney J
dc.contributor.authorGünther CS
dc.contributor.authorYoung W
dc.contributor.authorGearry RB
dc.contributor.authorHeenan PE
dc.contributor.authorTrower T
dc.contributor.authorKeenan JI
dc.contributor.authorTalley NJ
dc.contributor.authorMcNabb WC
dc.contributor.authorRoy NC
dc.contributor.editorJang C
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-10-22T20:20:17Z
dc.date.available2024-10-22T20:20:17Z
dc.date.issued2023-02-20
dc.description.abstractAmino acids are important in several biochemical pathways as precursors to neurotransmitters which impact biological processes previously linked to functional gastrointestinal disorders (FGIDs). Dietary protein consumption, metabolic host processes, and the gut microbiome can influence the plasma concentration of amino acids and neurotransmitters, and their uptake by tissues. The aim of this analysis was to quantify 19 proteogenic and 4 non-proteogenic amino acids and 19 neurotransmitters (including precursors and catabolites, herein referred to as neurotransmitters) to ascertain if their circulating concentrations differed between healthy participants and those with FGIDs. Plasma proteogenic and non-proteogenic amino acids and neurotransmitters were measured using ultra-performance liquid chromatography and liquid chromatography-mass spectrometry, respectively, from 165 participants (Rome IV: irritable bowel syndrome (IBS-constipation, IBS-diarrhea), functional constipation, functional diarrhea, and healthy controls). There were significant differences (p < 0.05) in pairwise comparisons between healthy controls and specific FGID groups for branched-chain amino acids (BCAAs), ornithine, and alpha-aminobutyric acid. No other significant differences were observed for the neurotransmitters or any other amino acids analyzed. Multivariate and bivariate correlation analyses between proteogenic and non-proteogenic amino acids and neurotransmitters for constipation (constipation (IBS-C and functional constipation) and phenotypes diarrhea (IBS-D and functional diarrhea)) and healthy controls suggested that associations between BCAAs, 5-hydroxytryptophan, and kynurenine in combination with tyrosine, 3,4-dihydroxyphenylalanine, and 3,4-dihydroxyphenylacetic acid and associations with gamma-aminobutyric acid, glutamate, asparagine, and serine are likely disrupted in FGID phenotypes. In conclusion, although correlations were evident between some proteogenic and non-proteogenic amino acids and neurotransmitters, the results showed minor concentration differences in plasma proteogenic and non-proteogenic amino acids, amino acid-derived metabolites, and neurotransmitters between FGID phenotypes and healthy controls.
dc.description.confidentialfalse
dc.edition.editionFebruary 2023
dc.format.pagination313-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/36837931
dc.identifier.citationJames SC, Fraser K, Cooney J, Günther CS, Young W, Gearry RB, Heenan PE, Trower T, Keenan JI, Talley NJ, McNabb WC, Roy NC. (2023). Concentrations of Plasma Amino Acids and Neurotransmitters in Participants with Functional Gut Disorders and Healthy Controls.. Metabolites. 13. 2. (pp. 313-).
dc.identifier.doi10.3390/metabo13020313
dc.identifier.eissn2218-1989
dc.identifier.elements-typejournal-article
dc.identifier.issn2218-1989
dc.identifier.number313
dc.identifier.piimetabo13020313
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71805
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2218-1989/13/2/313
dc.relation.isPartOfMetabolites
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectamino acids
dc.subjectfunctional gastrointestinal disorder
dc.subjectirritable bowel syndrome
dc.subjectneurotransmitters
dc.titleConcentrations of Plasma Amino Acids and Neurotransmitters in Participants with Functional Gut Disorders and Healthy Controls
dc.typeJournal article
pubs.elements-id460138
pubs.organisational-groupOther
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