The aetiology of wobbly possum disease: Reproduction of the disease with purified nidovirus.

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dc.citation.volume491
dc.contributor.authorGiles J
dc.contributor.authorPerrott M
dc.contributor.authorRoe W
dc.contributor.authorDunowska M
dc.date.available2016-04
dc.date.available2016-01-12
dc.date.issued2016-04
dc.description.abstractThe objective of this study was to investigate a role of a recently discovered marsupial nidovirus in the development of a neurological disease, termed wobbly possum disease (WPD), in the Australian brushtail possum (Trichosurus vulpecula). Four possums received 1 mL of a standard inoculum that had been prepared from tissues of WPD-affected possums, 4 possums received 1.8 mL (1 × 10(6) TCID50) of a cell lysate from inoculated cultures, and 4 possums received 1 mL (× 10(7) TCID50) of a purified WPD isolate. All but one possum that received infectious inocula developed neurological disease and histopathological lesions characteristic for WPD. High levels of viral RNA were detected in livers from all possums that received infectious inocula, but not from control possums. Altogether, our data provide strong experimental evidence for the causative involvement of WPD virus in development of a neurological disease in infected animals.
dc.description.publication-statusPublished
dc.format.extent20 - 26
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000372666000003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifier.citationVIROLOGY, 2016, 491 pp. 20 - 26
dc.identifier.doi10.1016/j.virol.2016.01.005
dc.identifier.elements-id259132
dc.identifier.harvestedMassey_Dark
dc.identifier.issn0042-6822
dc.relation.isPartOfVIROLOGY
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0042682216000088?via=ihub
dc.rightsUnder an Elsevier user license
dc.subjectArterivirus
dc.subjectWobbly possum disease
dc.subjectWPD
dc.subjectAustralian brushtail possum
dc.subjectTrichosurus vulpecula
dc.subjectKoch's postulates
dc.subjectAetiology
dc.subject.anzsrc06 Biological Sciences
dc.subject.anzsrc07 Agricultural and Veterinary Sciences
dc.subject.anzsrc11 Medical and Health Sciences
dc.titleThe aetiology of wobbly possum disease: Reproduction of the disease with purified nidovirus.
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Veterinary Science
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