Pharmacokinetics and efficacy of intravenous famotidine in adult cattle.

Simple item page
dc.citation.issue3
dc.citation.volume32
dc.contributor.authorBalcomb CC
dc.contributor.authorHeller MC
dc.contributor.authorChigerwe M
dc.contributor.authorKnych HK
dc.contributor.authorMeyer AM
dc.coverage.spatialUnited States
dc.date.accessioned2024-08-14T01:42:15Z
dc.date.available2024-08-14T01:42:15Z
dc.date.issued2018-05-01
dc.description.abstractBACKGROUND: Abomasal ulceration is recognized in neonatal and adult cattle, but research regarding treatment is limited. Histamine-2 receptor antagonists (H2 RA), such as famotidine, are used clinically with little evidence-based research about efficacy in adult cattle. HYPOTHESIS AND OBJECTIVES: Intravenous famotidine administered at 0.4 mg/kg will increase the pH of abomasal outflow digesta compared to saline control in adult cattle. The objectives were to assess the effect of famotidine, administered as a single dose and as multiple doses, on abomasal outflow fluid pH in adult cattle. A third objective was to describe the pharmacokinetic parameters of IV famotidine in cattle. ANIMALS: Four clinically healthy adult Angus-cross steers previously fitted with duodenal cannulae placed orad to the biliary and pancreatic ducts. METHODS: Randomized, 2-way cross-over clinical trial. Steers received IV famotidine (0.4 mg/kg) as a single and 3-dose regimen (every 8 hours) versus saline control. Blood for analysis of serum famotidine concentration was collected intermittently for 12 hours, and abomasal outflow fluid pH was measured at intervals for a 24-hour period. After a 34-hour washout period, the opposite treatments were administered and the sampling repeated. RESULTS: Abomasal outflow fluid pH was higher in steers treated with famotidine for up to 4 hours after a single dose but the effect decreased with subsequent doses. The median (range) elimination half-life was 3.33 (3.21-3.54) hours. CONCLUSIONS AND CLINICAL IMPORTANCE: Famotidine may be useful for treatment or prevention of abomasal ulceration in adult cattle, but the duration of effect may decrease with time.
dc.description.confidentialfalse
dc.edition.editionMay 2018
dc.format.pagination1283-1289
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/29572958
dc.identifier.citationBalcomb CC, Heller MC, Chigerwe M, Knych HK, Meyer AM. (2018). Pharmacokinetics and efficacy of intravenous famotidine in adult cattle.. J Vet Intern Med. 32. 3. (pp. 1283-1289).
dc.identifier.doi10.1111/jvim.15080
dc.identifier.eissn1939-1676
dc.identifier.elements-typejournal-article
dc.identifier.issn0891-6640
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71286
dc.languageeng
dc.publisherJournal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine
dc.publisher.urihttps://onlinelibrary.wiley.com/doi/10.1111/jvim.15080
dc.relation.isPartOfJ Vet Intern Med
dc.rights(c) 2018 The Author/s
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectabomasum
dc.subjectbovine
dc.subjectgastroprotectant
dc.subjectulcer
dc.subjectAbomasum
dc.subjectAnimals
dc.subjectCattle
dc.subjectCross-Over Studies
dc.subjectDrug Administration Schedule
dc.subjectFamotidine
dc.subjectHistamine H2 Antagonists
dc.subjectHydrogen-Ion Concentration
dc.subjectInjections, Intravenous
dc.subjectMale
dc.titlePharmacokinetics and efficacy of intravenous famotidine in adult cattle.
dc.typeJournal article
pubs.elements-id445469
pubs.organisational-groupOther
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
445469 PDF.pdf
Size:
710.81 KB
Format:
Adobe Portable Document Format
Description:
Published version.pdf
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
9.22 KB
Format:
Plain Text
Description:
Download
Collections
Journal Articles