Gut Microbial Metabolites and Biochemical Pathways Involved in Irritable Bowel Syndrome: Effects of Diet and Nutrition on the Microbiome

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dc.citation.issue5
dc.citation.volume150
dc.contributor.authorJames SC
dc.contributor.authorFraser K
dc.contributor.authorYoung W
dc.contributor.authorMcNabb WC
dc.contributor.authorRoy NC
dc.coverage.spatialUnited States
dc.date.accessioned2024-10-17T22:15:26Z
dc.date.available2024-10-17T22:15:26Z
dc.date.issued2020-05
dc.description.abstractThe food we consume and its interactions with the host and their gut microbiota affect normal gut function and health. Functional gut disorders (FGDs), including irritable bowel syndrome (IBS), can result from negative effects of these interactions, leading to a reduced quality of life. Certain foods exacerbate or reduce the severity and prevalence of FGD symptoms. IBS can be used as a model of perturbation from normal gut function with which to study the impact of foods and diets on the severity and symptoms of FGDs and understand how critical processes and biochemical mechanisms contribute to this impact. Analyzing the complex interactions between food, host, and microbial metabolites gives insights into the pathways and processes occurring in the gut which contribute to FGDs. The following review is a critical discussion of the literature regarding metabolic pathways and dietary interventions relevant to FGDs. Many metabolites, for example bile acids, SCFAs, vitamins, amino acids, and neurotransmitters, can be altered by dietary intake, and could be valuable for identifying perturbations in metabolic pathways that distinguish a "normal, healthy" gut from a "dysfunctional, unhealthy" gut. Dietary interventions for reducing symptoms of FGDs are becoming more prevalent, but studies investigating the underlying mechanisms linked to host, microbiome, and metabolite interactions are less common. Therefore, we aim to evaluate the recent literature to assist with further progression of research in this field.
dc.description.confidentialfalse
dc.edition.editionMay 2020
dc.format.pagination1012-1021
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/31891398
dc.identifier.citationJames SC, Fraser K, Young W, McNabb WC, Roy NC. (2020). Gut Microbial Metabolites and Biochemical Pathways Involved in Irritable Bowel Syndrome: Effects of Diet and Nutrition on the Microbiome.. J Nutr. 150. 5. (pp. 1012-1021).
dc.identifier.doi10.1093/jn/nxz302
dc.identifier.eissn1541-6100
dc.identifier.elements-typejournal-article
dc.identifier.issn0022-3166
dc.identifier.piiS0022-3166(22)02167-8
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71752
dc.languageeng
dc.publisherElsevier Inc on behalf of the American Society for Nutrition
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S0022316622021678
dc.relation.isPartOfJ Nutr
dc.rights(c) 2019 The Author/s
dc.rightsCC BY-NC 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectdiet
dc.subjectfunctional gut disorder
dc.subjectgut microbiota
dc.subjectirritable bowel syndrome
dc.subjectmetabolites
dc.subjectDiet
dc.subjectGastrointestinal Microbiome
dc.subjectHumans
dc.subjectIrritable Bowel Syndrome
dc.subjectNutritional Status
dc.titleGut Microbial Metabolites and Biochemical Pathways Involved in Irritable Bowel Syndrome: Effects of Diet and Nutrition on the Microbiome
dc.typeJournal article
pubs.elements-id429107
pubs.organisational-groupOther
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