Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2

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dc.citation.volume13
dc.contributor.authordos Santos AAC
dc.contributor.authorRodrigues LE
dc.contributor.authorAlecrim-Zeza AL
dc.contributor.authorde Araújo Ferreira L
dc.contributor.authorTrettel CDS
dc.contributor.authorGimenes GM
dc.contributor.authorda Silva AF
dc.contributor.authorSousa-Filho CPB
dc.contributor.authorSerdan TDA
dc.contributor.authorLevada-Pires AC
dc.contributor.authorHatanaka E
dc.contributor.authorBorges FT
dc.contributor.authorde Barros MP
dc.contributor.authorCury-Boaventura MF
dc.contributor.authorBertolini GL
dc.contributor.authorCassolla P
dc.contributor.authorMarzuca-Nassr GN
dc.contributor.authorVitzel KF
dc.contributor.authorPithon-Curi TC
dc.contributor.authorMasi LN
dc.contributor.authorCuri R
dc.contributor.authorGorjao R
dc.contributor.authorHirabara SM
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-08-10T23:32:02Z
dc.date.accessioned2023-09-04T01:41:08Z
dc.date.available2022-11-10
dc.date.available2023-08-10T23:32:02Z
dc.date.available2023-09-04T01:41:08Z
dc.date.issued2022
dc.date.updated2023-08-10T23:11:30Z
dc.description.abstractCoronavirus disease 2019 (COVID-19) is triggered by the SARS-CoV-2, which is able to infect and cause dysfunction not only in lungs, but also in multiple organs, including central nervous system, skeletal muscle, kidneys, heart, liver, and intestine. Several metabolic disturbances are associated with cell damage or tissue injury, but the mechanisms involved are not yet fully elucidated. Some potential mechanisms involved in the COVID-19-induced tissue dysfunction are proposed, such as: (a) High expression and levels of proinflammatory cytokines, including TNF-α IL-6, IL-1β, INF-α and INF-β, increasing the systemic and tissue inflammatory state; (b) Induction of oxidative stress due to redox imbalance, resulting in cell injury or death induced by elevated production of reactive oxygen species; and (c) Deregulation of the renin-angiotensin-aldosterone system, exacerbating the inflammatory and oxidative stress responses. In this review, we discuss the main metabolic disturbances observed in different target tissues of SARS-CoV-2 and the potential mechanisms involved in these changes associated with the tissue dysfunction.
dc.format.extent1037467-
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/36439786
dc.identifier.citationDos Santos AAC, Rodrigues LE, Alecrim-Zeza AL, de Araújo Ferreira L, Trettel CDS, Gimenes GM, da Silva AF, Sousa-Filho CPB, Serdan TDA, Levada-Pires AC, Hatanaka E, Borges FT, de Barros MP, Cury-Boaventura MF, Bertolini GL, Cassolla P, Marzuca-Nassr GN, Vitzel KF, Pithon-Curi TC, Masi LN, Curi R, Gorjao R, Hirabara SM. (2022). Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2.. Front Microbiol. 13. (pp. 1037467-).
dc.identifier.doi10.3389/fmicb.2022.1037467
dc.identifier.eissn1664-302X
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn1664-302X
dc.identifier.urihttp://hdl.handle.net/10179/19926
dc.languageeng
dc.publisherFrontiers Media SA
dc.relation.isPartOfFront Microbiol
dc.rights© 2022 Santos, Rodrigues, Alecrim-Zeza, de Araújo Ferreira, Trettel, Gimenes, Silva, Sousa-Filho, Serdan, Levada-Pires, Hatanaka, Borges, de Barros, Cury Boaventura, Bertolini, Cassolla, Marzuca Nassr, Vitzel, Pithon-Curi, Masi, Curi, Gorjao and Hirabara. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectSARS-CoV-2
dc.subjectinflammation
dc.subjectmetabolism
dc.subjectoxidative stress
dc.subjectrenin-angiotensin-aldosterone system
dc.titleMolecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2
dc.typeJournal article
pubs.elements-id458427
pubs.organisational-groupOther
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