Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2
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Date
2022
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Frontiers Media SA
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© 2022 Santos, Rodrigues, Alecrim-Zeza,
de Araújo Ferreira, Trettel, Gimenes, Silva,
Sousa-Filho, Serdan, Levada-Pires,
Hatanaka, Borges, de Barros, Cury Boaventura, Bertolini, Cassolla, Marzuca Nassr, Vitzel, Pithon-Curi, Masi, Curi,
Gorjao and Hirabara. This is an open access article distributed under the terms
of the Creative Commons Attribution
License (CC BY). The use, distribution or
reproduction in other forums is permitted,
provided the original author(s) and the
copyright owner(s) are credited and that
the original publication in this journal is
cited, in accordance with accepted
academic practice. No use, distribution or
reproduction is permitted which does not
comply with these terms.
Abstract
Coronavirus disease 2019 (COVID-19) is triggered by the SARS-CoV-2, which is able to infect and cause dysfunction not only in lungs, but also in multiple organs, including central nervous system, skeletal muscle, kidneys, heart, liver, and intestine. Several metabolic disturbances are associated with cell damage or tissue injury, but the mechanisms involved are not yet fully elucidated. Some potential mechanisms involved in the COVID-19-induced tissue dysfunction are proposed, such as: (a) High expression and levels of proinflammatory cytokines, including TNF-α IL-6, IL-1β, INF-α and INF-β, increasing the systemic and tissue inflammatory state; (b) Induction of oxidative stress due to redox imbalance, resulting in cell injury or death induced by elevated production of reactive oxygen species; and (c) Deregulation of the renin-angiotensin-aldosterone system, exacerbating the inflammatory and oxidative stress responses. In this review, we discuss the main metabolic disturbances observed in different target tissues of SARS-CoV-2 and the potential mechanisms involved in these changes associated with the tissue dysfunction.
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Keywords
SARS-CoV-2, inflammation, metabolism, oxidative stress, renin-angiotensin-aldosterone system
Citation
Dos Santos AAC, Rodrigues LE, Alecrim-Zeza AL, de Araújo Ferreira L, Trettel CDS, Gimenes GM, da Silva AF, Sousa-Filho CPB, Serdan TDA, Levada-Pires AC, Hatanaka E, Borges FT, de Barros MP, Cury-Boaventura MF, Bertolini GL, Cassolla P, Marzuca-Nassr GN, Vitzel KF, Pithon-Curi TC, Masi LN, Curi R, Gorjao R, Hirabara SM. (2022). Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2.. Front Microbiol. 13. (pp. 1037467-).