Relationship between Cardiopulmonary, Mitochondrial and Autonomic Nervous System Function Improvement after an Individualised Activity Programme upon Chronic Fatigue Syndrome Patients

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dc.citation.issue7
dc.citation.volume10
dc.contributor.authorKujawski S
dc.contributor.authorCossington J
dc.contributor.authorSłomko J
dc.contributor.authorZawadka-Kunikowska M
dc.contributor.authorTafil-Klawe M
dc.contributor.authorKlawe JJ
dc.contributor.authorBuszko K
dc.contributor.authorJakovljevic DG
dc.contributor.authorKozakiewicz M
dc.contributor.authorMorten KJ
dc.contributor.authorDawes H
dc.contributor.authorStrong JWL
dc.contributor.authorMurovska M
dc.contributor.authorVan Oosterwijck J
dc.contributor.authorEstevez-Lopez F
dc.contributor.authorNewton JL
dc.contributor.authorHodges L
dc.contributor.authorZalewski P
dc.contributor.authorOn Behalf Of The European Network On Me/Cfs Euromene
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-08-24T02:50:09Z
dc.date.accessioned2023-09-04T01:41:34Z
dc.date.available2021-04-06
dc.date.available2023-08-24T02:50:09Z
dc.date.available2023-09-04T01:41:34Z
dc.date.issued2021-04
dc.date.updated2023-08-20T22:39:17Z
dc.descriptionCopyright: © 2021 by the authorsen_US
dc.description.abstractBackground: The therapeutic effects of exercise from structured activity programmes have recently been questioned; as a result, this study examines the impact of an Individualised Activity Program (IAP) on the relationship with cardiovascular, mitochondrial and fatigue parameters. Methods: Chronic fatigue syndrome (CFS) patients were assessed using Chalder Fatigue Questionnaire (CFQ), Fatigue Severity Score (FSS) and the Fatigue Impact Scale (FIS). VO2peak, VO2submax and heart rate (HR) were assessed using cardiopulmonary exercise testing. Mfn1 and Mfn2 levels in plasma were assessed. A Task Force Monitor was used to assess ANS functioning in supine rest and in response to the Head-Up Tilt Test (HUTT). Results: Thirty-four patients completed 16 weeks of the IAP. The CFQ, FSS and FIS scores decreased significantly along with a significant increase in Mfn1 and Mfn2 levels (p = 0.002 and p = 0.00005, respectively). The relationships between VO2 peak and Mfn1 increase in response to IAP (p = 0.03) and between VO2 at anaerobic threshold and ANS response to the HUTT (p = 0.03) were noted. Conclusions: It is concluded that IAP reduces fatigue and improves functional performance along with changes in autonomic and mitochondrial function. However, caution must be applied as exercise was not well tolerated by 51% of patients.
dc.format.extent1542-
dc.identifierARTN 1542
dc.identifierjcm10071542
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/33917586
dc.identifier.citationKujawski S, Cossington J, Słomko J, Zawadka-Kunikowska M, Tafil-Klawe M, Klawe JJ, Buszko K, Jakovljevic DG, Kozakiewicz M, Morten KJ, Dawes H, Strong JWL, Murovska M, Van Oosterwijck J, Estevez-Lopez F, Newton JL, Hodges L, Zalewski P, On Behalf Of The European Network On Me/Cfs Euromene . (2021). Relationship between Cardiopulmonary, Mitochondrial and Autonomic Nervous System Function Improvement after an Individualised Activity Programme upon Chronic Fatigue Syndrome Patients.. J Clin Med. 10. 7. (pp. 1542-).
dc.identifier.doi10.3390/jcm10071542
dc.identifier.eissn2077-0383
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn2077-0383
dc.identifier.urihttp://hdl.handle.net/10179/19985
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.relation.isPartOfJ Clin Med
dc.rightsCC BYen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectautonomic nervous system
dc.subjectchronic fatigue syndrome
dc.subjectexercise
dc.subjectmitofusin
dc.subjectmyalgic encephalomyelitis
dc.subjectoxygen consumption
dc.titleRelationship between Cardiopulmonary, Mitochondrial and Autonomic Nervous System Function Improvement after an Individualised Activity Programme upon Chronic Fatigue Syndrome Patients
dc.typeJournal article
pubs.elements-id444815
pubs.organisational-groupOther
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