Birth weight and prematurity with lung function at ~17.5 years: "Children of 1997" birth cohort.
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Date
2020-01-15
Open Access Location
Journal Title
Journal ISSN
Volume Title
Publisher
Springer Nature Limited
Rights
(c) 2020 The Author/s
CC BY 4.0
CC BY 4.0
Abstract
We aimed to determine if prematurity and lower birth weight are associated with poorer lung function in a non-western developed setting with less marked confounding by socioeconomic position. Using multivariable linear regression in Hong Kong's "Children of 1997" birth cohort, adjusted associations of prematurity and birth weight with forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and forced expiratory flow at 25-75% of the pulmonary volume (FEF25-75%) at ~17.5 years were assessed. Associations for birth weight were stronger in boys for FEV1 (boys: 0.31 L, 95% confidence interval (CI) 0.24 to 0.38, girls: 0.18 L, 95% CI 0.12 to 0.25), FVC (boys: 0.36 L, 95% CI 0.27 to 0.44, girls: 0.22 L, 95% CI 0.15 to 0.28) and FEF25-75% (boys: 0.35 L, 95% CI 0.21 to 0.49, girls: 0.22 L, 95% CI 0.09 to 0.34) adjusted for age, socioeconomic position and infant and maternal characteristics. Similarly adjusted, preterm birth (compared to full-term birth) was associated with lower FEV1/FVC and FEF25-75%. Thus, associations of lower birth weight, especially in boys, and prematurity with poorer lung function at 17.5 years were found. Identifying underlying mechanism might contribute to the improvement of pulmonary health and the prevention of adult respiratory illness.
Description
Keywords
Birth Weight, Female, Follow-Up Studies, Forced Expiratory Volume, Humans, Infant, Newborn, Lung, Male, Premature Birth, Respiratory Function Tests
Citation
He B, Kwok MK, Au Yeung SL, Lin SL, Leung JYY, Hui LL, Li AM, Leung GM, Schooling CM. (2020). Birth weight and prematurity with lung function at ~17.5 years: "Children of 1997" birth cohort.. Sci Rep. 10. 1. (pp. 341-).