Birth weight and prematurity with lung function at ~17.5 years: "Children of 1997" birth cohort.

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dc.citation.issue1
dc.citation.volume10
dc.contributor.authorHe B
dc.contributor.authorKwok MK
dc.contributor.authorAu Yeung SL
dc.contributor.authorLin SL
dc.contributor.authorLeung JYY
dc.contributor.authorHui LL
dc.contributor.authorLi AM
dc.contributor.authorLeung GM
dc.contributor.authorSchooling CM
dc.coverage.spatialEngland
dc.date.accessioned2024-09-23T02:49:17Z
dc.date.available2024-09-23T02:49:17Z
dc.date.issued2020-01-15
dc.description.abstractWe aimed to determine if prematurity and lower birth weight are associated with poorer lung function in a non-western developed setting with less marked confounding by socioeconomic position. Using multivariable linear regression in Hong Kong's "Children of 1997" birth cohort, adjusted associations of prematurity and birth weight with forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and forced expiratory flow at 25-75% of the pulmonary volume (FEF25-75%) at ~17.5 years were assessed. Associations for birth weight were stronger in boys for FEV1 (boys: 0.31 L, 95% confidence interval (CI) 0.24 to 0.38, girls: 0.18 L, 95% CI 0.12 to 0.25), FVC (boys: 0.36 L, 95% CI 0.27 to 0.44, girls: 0.22 L, 95% CI 0.15 to 0.28) and FEF25-75% (boys: 0.35 L, 95% CI 0.21 to 0.49, girls: 0.22 L, 95% CI 0.09 to 0.34) adjusted for age, socioeconomic position and infant and maternal characteristics. Similarly adjusted, preterm birth (compared to full-term birth) was associated with lower FEV1/FVC and FEF25-75%. Thus, associations of lower birth weight, especially in boys, and prematurity with poorer lung function at 17.5 years were found. Identifying underlying mechanism might contribute to the improvement of pulmonary health and the prevention of adult respiratory illness.
dc.description.confidentialfalse
dc.format.pagination341-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/31941940
dc.identifier.citationHe B, Kwok MK, Au Yeung SL, Lin SL, Leung JYY, Hui LL, Li AM, Leung GM, Schooling CM. (2020). Birth weight and prematurity with lung function at ~17.5 years: "Children of 1997" birth cohort.. Sci Rep. 10. 1. (pp. 341-).
dc.identifier.doi10.1038/s41598-019-56086-7
dc.identifier.eissn2045-2322
dc.identifier.elements-typejournal-article
dc.identifier.issn2045-2322
dc.identifier.number341
dc.identifier.pii10.1038/s41598-019-56086-7
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71497
dc.languageeng
dc.publisherSpringer Nature Limited
dc.publisher.urihttps://www.nature.com/articles/s41598-019-56086-7
dc.relation.isPartOfSci Rep
dc.rights(c) 2020 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBirth Weight
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectForced Expiratory Volume
dc.subjectHumans
dc.subjectInfant, Newborn
dc.subjectLung
dc.subjectMale
dc.subjectPremature Birth
dc.subjectRespiratory Function Tests
dc.titleBirth weight and prematurity with lung function at ~17.5 years: "Children of 1997" birth cohort.
dc.typeJournal article
pubs.elements-id491215
pubs.organisational-groupCollege of Health
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