Occupational exposure to organic dust and risk of lymphoma subtypes in the EPILYMPH case-control study

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dc.citation.issue1
dc.citation.volume47
dc.contributor.authorCocco P
dc.contributor.authorSatta G
dc.contributor.authorMeloni F
dc.contributor.authorPilia I
dc.contributor.authorAhmed F
dc.contributor.authorBecker N
dc.contributor.authorCasabonne D
dc.contributor.authorde Sanjosé S
dc.contributor.authorForetova L
dc.contributor.authorMaynadié M
dc.contributor.authorNieters A
dc.contributor.authorStaines A
dc.contributor.author't Mannetje A
dc.contributor.authorZucca M
dc.contributor.authorEnnas MG
dc.contributor.authorCampagna M
dc.contributor.authorDe Matteis S
dc.contributor.authorBenavente Y
dc.date.accessioned2023-07-11T20:00:40Z
dc.date.accessioned2023-09-04T01:40:21Z
dc.date.available2023-07-11T20:00:40Z
dc.date.available2023-09-04T01:40:21Z
dc.date.issued2021-01-01
dc.descriptionThis work is licensed under a Creative Commons Attribution 4.0 International License.
dc.description.abstractObjectives This study aimed to estimate the risk of lymphoma and its major subtypes in relation to occupational exposure to specific organic dusts. Methods We explored the association in 1853 cases and 1997 controls who participated in the EpiLymph case-control study, conducted in six European countries in 1998-2004. Based on expert assessment of lifetime occupational exposures, we calculated the risk of the major lymphoma subtypes associated with exposure to six specific organic dusts, namely, flour, hardwood, softwood, natural textile, synthetic textile, and leather, and two generic (any types) groups: wood and textile dusts. Risk was predicted with unconditional regression modeling, adjusted by age, gender, study center, and education. Results We observed a 2.1-fold increase in risk of follicular lymphoma associated with ever exposure to leather dust [95% confidence interval (CI) 1.01-4.20]. After excluding subjects who ever worked in a farm or had ever been exposed to solvents, risk of B-cell lymphoma was elevated in relation to ever exposure to leather dust [odd ratio (OR) 2.2, 95% CI 1.00-4.78], but it was not supported by increasing trends with the exposure metrics. Risk of Hodgkin lymphoma was elevated (OR 2.0, 95% CI 0.95-4.30) for exposure to textile dust, with consistent upward trends by cumulative exposure and three independent exposure metrics combined (P=0.023, and P=0.0068, respectively). Conclusions Future, larger studies might provide further insights into the nature of the association we observed between exposure to textile dust and risk of Hodgkin lymphoma.
dc.description.publication-statusPublished
dc.format.extent42 - 51
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000600200200006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifier.citationSCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH, 2021, 47 (1), pp. 42 - 51
dc.identifier.doi10.5271/sjweh.3925
dc.identifier.eissn1795-990X
dc.identifier.elements-id447253
dc.identifier.harvestedMassey_Dark
dc.identifier.issn0355-3140
dc.identifier.urihttp://hdl.handle.net/10179/19819
dc.publisherNordic Association of Occupational Safety and Health
dc.relation.isPartOfSCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH
dc.rights(c) The author/s (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectB cell lymphoma
dc.subjectepidemiology
dc.subjectflour dust
dc.subjectHodgkin lymphoma
dc.subjectleather dust
dc.subjecttextile dust
dc.subjectwood dust
dc.subject.anzsrc1117 Public Health and Health Services
dc.subject.anzsrc1701 Psychology
dc.titleOccupational exposure to organic dust and risk of lymphoma subtypes in the EPILYMPH case-control study
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Health
pubs.organisational-group/Massey University/College of Health/Research Centre for Hauora and Health
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