Dynamics of bacterial adaptation
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Date
2021-04-12
Open Access Location
Journal Title
Journal ISSN
Volume Title
Publisher
Portland Press Limited on behalf of the Biochemical Society
Rights
Abstract
Determining pattern in the dynamics of population evolution is a long-standing focus of evolutionary biology. Complementing the study of natural populations, microbial laboratory evolution experiments have become an important tool for addressing these dynamics because they allow detailed and replicated analysis of evolution in response to controlled environmental and genetic conditions. Key findings include a tendency for smoothly declining rates of adaptation during selection in constant environments, at least in part a reflection of antagonism between accumulating beneficial mutations, and a large number of beneficial mutations available to replicate populations leading to significant, but relatively low genetic parallelism, even as phenotypic characteristics show high similarity. Together, there is a picture of adaptation as a process with a varied and largely unpredictable genetic basis leading to much more similar phenotypic outcomes. Increasing sophistication of sequencing and genetic tools will allow insight into mechanisms behind these and other patterns.
Description
Keywords
adaptation, fitness landscape, gene interactions, microbial genetics, Adaptation, Physiological, Bacteria, Evolution, Molecular, Genetic Fitness, Genetic Variation, Genotype, Mutation, Plasmids, Population Dynamics, Selection, Genetic
Citation
Lai H-Y, Cooper TF. (2021). Dynamics of bacterial adaptation.. Biochem Soc Trans. 49. 2. (pp. 945-951).