Dynamics of bacterial adaptation

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dc.citation.issue2
dc.citation.volume49
dc.contributor.authorLai H-Y
dc.contributor.authorCooper TF
dc.coverage.spatialEngland
dc.date.accessioned2023-12-05T19:56:22Z
dc.date.accessioned2024-07-25T06:52:13Z
dc.date.available2021-04-12
dc.date.available2023-12-05T19:56:22Z
dc.date.available2024-07-25T06:52:13Z
dc.date.issued2021-04-12
dc.description.abstractDetermining pattern in the dynamics of population evolution is a long-standing focus of evolutionary biology. Complementing the study of natural populations, microbial laboratory evolution experiments have become an important tool for addressing these dynamics because they allow detailed and replicated analysis of evolution in response to controlled environmental and genetic conditions. Key findings include a tendency for smoothly declining rates of adaptation during selection in constant environments, at least in part a reflection of antagonism between accumulating beneficial mutations, and a large number of beneficial mutations available to replicate populations leading to significant, but relatively low genetic parallelism, even as phenotypic characteristics show high similarity. Together, there is a picture of adaptation as a process with a varied and largely unpredictable genetic basis leading to much more similar phenotypic outcomes. Increasing sophistication of sequencing and genetic tools will allow insight into mechanisms behind these and other patterns.
dc.description.confidentialfalse
dc.edition.editionApril 2021
dc.format.pagination945-951
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/33843990
dc.identifier.citationLai H-Y, Cooper TF. (2021). Dynamics of bacterial adaptation.. Biochem Soc Trans. 49. 2. (pp. 945-951).
dc.identifier.doi10.1042/BST20200885
dc.identifier.eissn1470-8752
dc.identifier.elements-typejournal-article
dc.identifier.issn0300-5127
dc.identifier.pii228275
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71070
dc.languageeng
dc.publisherPortland Press Limited on behalf of the Biochemical Society
dc.publisher.urihttps://portlandpress.com/biochemsoctrans/article/49/2/945/228275/Dynamics-of-bacterial-adaptation
dc.relation.isPartOfBiochem Soc Trans
dc.subjectadaptation
dc.subjectfitness landscape
dc.subjectgene interactions
dc.subjectmicrobial genetics
dc.subjectAdaptation, Physiological
dc.subjectBacteria
dc.subjectEvolution, Molecular
dc.subjectGenetic Fitness
dc.subjectGenetic Variation
dc.subjectGenotype
dc.subjectMutation
dc.subjectPlasmids
dc.subjectPopulation Dynamics
dc.subjectSelection, Genetic
dc.titleDynamics of bacterial adaptation
dc.typeJournal article
pubs.elements-id444416
pubs.organisational-groupOther
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