Prospective Associations between Single Foods, Alzheimer’s Dementia and Memory Decline in the Elderly

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dc.citation.issue7
dc.citation.volume10
dc.contributor.authorFischer K
dc.contributor.authorMelo van Lent D
dc.contributor.authorWolfsgruber S
dc.contributor.authorWeinhold L
dc.contributor.authorKleineidam L
dc.contributor.authorBickel H
dc.contributor.authorScherer M
dc.contributor.authorEisele M
dc.contributor.authorvan den Bussche H
dc.contributor.authorWiese B
dc.contributor.authorKönig H-H
dc.contributor.authorWeyerer S
dc.contributor.authorPentzek M
dc.contributor.authorRöhr S
dc.contributor.authorMaier W
dc.contributor.authorJessen F
dc.contributor.authorSchmid M
dc.contributor.authorRiedel-Heller SG
dc.contributor.authorWagner M
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-12-15T01:22:42Z
dc.date.accessioned2024-07-25T06:33:51Z
dc.date.available2018-06-29
dc.date.available2023-12-15T01:22:42Z
dc.date.available2024-07-25T06:33:51Z
dc.date.issued2018-07
dc.description.abstractBackground: Evidence whether single “cognitive health” foods could prevent cognitive decline is limited. We investigated whether dietary intake of red wine, white wine, coffee, green tea, olive oil, fresh fish, fruits and vegetables, red meat and sausages, assessed by a single-food-questionnaire, would be associated with either incident Alzheimer’s dementia (AD) or verbal memory decline. Methods: Participants aged 75+ of the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe) cohort were regularly followed over 10 years (n = 2622; n = 418 incident AD cases). Multivariable-adjusted joint modeling of repeated-measures and survival analysis was used, taking gender and Apolipoprotein E4 (APOE ε4) genotype into account as possible effect modifiers. Results: Only higher red wine intake was associated with a lower incidence of AD (HR = 0.92; P = 0.045). Interestingly, this was true only for men (HR = 0.82; P < 0.001), while in women higher red wine intake was associated with a higher incidence of AD (HR = 1.15; P = 0.044), and higher white wine intake with a more pronounced memory decline over time (HR = −0.13; P = 0.052). Conclusion: We found no evidence for these single foods to be protective against cognitive decline, with the exception of red wine, which reduced the risk for AD only in men. Women could be more susceptible to detrimental effects of alcohol.
dc.format.paginationE852-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/29966314
dc.identifier.citationFischer K, Melo van Lent D, Wolfsgruber S, Weinhold L, Kleineidam L, Bickel H, Scherer M, Eisele M, van den Bussche H, Wiese B, König H-H, Weyerer S, Pentzek M, Röhr S, Maier W, Jessen F, Schmid M, Riedel-Heller SG, Wagner M. (2018). Prospective Associations between Single Foods, Alzheimer's Dementia and Memory Decline in the Elderly.. Nutrients. 10. 7. (pp. E852-).
dc.identifier.doi10.3390/nu10070852
dc.identifier.eissn2072-6643
dc.identifier.elements-typejournal-article
dc.identifier.issn2072-6643
dc.identifier.piinu10070852
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70430
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.relation.isPartOfNutrients
dc.rights(c) The author/sen
dc.rights.licenseCC BY 4.0en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectAlzheimer´s dementia
dc.subjectapolipoprotein E ε4
dc.subjectcognitive decline
dc.subjectdementia
dc.subjectfood intake
dc.subjectgender
dc.subjectmemory decline
dc.subjectAge Factors
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAlzheimer Disease
dc.subjectCognition
dc.subjectCognitive Aging
dc.subjectFemale
dc.subjectFood
dc.subjectGeriatric Assessment
dc.subjectGermany
dc.subjectHumans
dc.subjectIncidence
dc.subjectMale
dc.subjectMemory
dc.subjectMemory Disorders
dc.subjectMental Status and Dementia Tests
dc.subjectNeuropsychological Tests
dc.subjectProspective Studies
dc.subjectProtective Factors
dc.subjectRisk Factors
dc.subjectSex Factors
dc.subjectTime Factors
dc.subjectWine
dc.titleProspective Associations between Single Foods, Alzheimer’s Dementia and Memory Decline in the Elderly
dc.typeJournal article
pubs.elements-id455106
pubs.organisational-groupOther
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