Differential effects of saturated and n-6 PUFA on blood lipids when co-administered with n-3 PUFA

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dc.citation.volume1
dc.contributor.authorDias CB
dc.contributor.authorWood LG
dc.contributor.authorGarg ML
dc.coverage.spatialHobart, Australia
dc.date.available12/12/2014
dc.date.finish-date28/11/2014
dc.date.issued12/12/2014
dc.date.start-date26/11/2014
dc.description.abstractBackground/Aims: The influence of diets rich in saturated fatty acids (SFA) or n-6PUFA in modulating blood lipid levels remains unclear. Recently we hypothesised that the lipemic effects of saturated fats are dependent on n-3PUFA status. This study aimed to examine the effects of consuming diets rich in SFA or n-6PUFA when co-administered with marine n-3PUFA. Methods: This was a randomised, controlled, parallel, dietary intervention trial involving 16 healthy adults aged 18 to 65 years. Subjects consumed a diet high in either SFA or n-6PUFA, each supplemented with 2.4g n-3PUFA daily for 6 weeks. Blood samples were collected after an overnight fast, at baseline and post-intervention, for analysis of blood lipid profile. Results: A reduction in plasma triglyceride levels was noted post-intervention, which was similar following consumption of the SFA+n-3PUFA or the n-6PUFA+n-3PUFA diets (28% versus 27% respectively). The SFA diet caused a significant rise in LDL (P=0.043) and HDL-cholesterol (P=0.05), while the n-6PUFA had no effect on LDL or HDL-cholesterol levels. Total/HDL-cholesterol or LDL/HDL-cholesterol ratios were not significantly different post-intervention for either of the diets. The change in total/HDL-cholesterol or LDL/HDL-cholesterol ratios following SFA diet was also similar to those on n-6PUFA diet. Conclusions: Dietary SFA and n-6PUFA differentially modulates plasma lipid profile when co-administered with n-3PUFA. The mechanism and consequence of concomitant increase in HDL and LDL-cholesterol following saturated fat consumption in association with n-3PUFA are worthy of further examination. Funding source(s): CBD was supported by a scholarship from the Coordenação Nacional de Desenvolvimento Científico e Tecnológico, Brazil.
dc.description.confidentialFALSE
dc.format.extent10 - 10 (1)
dc.identifier.citationJournal of Nutrition and Intermediary Metabolism, 2014, 1 pp. 10 - 10 (1)
dc.identifier.doi10.1016/j.jnim.2014.10.025
dc.identifier.elements-id382341
dc.identifier.harvestedMassey_Dark
dc.identifier.issn2352-3859
dc.identifier.urihttps://hdl.handle.net/10179/13270
dc.publisherElsevier
dc.relation.isPartOfJournal of Nutrition and Intermediary Metabolism
dc.sourceAnnual meeting of the Nutrition Society of Australia
dc.titleDifferential effects of saturated and n-6 PUFA on blood lipids when co-administered with n-3 PUFA
dc.typeconference
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/Other
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