Insights into the pathogenesis of catastrophic spontaneous humeral fractures in first-lactation dairy cows

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dc.citation.issue7
dc.citation.volume65
dc.contributor.authorWehrle-Martinez AS
dc.contributor.authorLawrence KE
dc.contributor.authorBack PJ
dc.contributor.authorRogers CW
dc.contributor.authorGibson MJ
dc.contributor.authorDittmer KE
dc.contributor.editorEastwood C
dc.date.accessioned2025-05-23T02:45:01Z
dc.date.available2025-05-23T02:45:01Z
dc.date.issued2025-05-06
dc.description.abstractSpontaneous humeral fractures in first-lactation dairy cows have introduced significant challenges to the dairy industry in New Zealand, impacting animal welfare, farm economics, and veterinary practices. This review synthesizes current knowledge on the pathogenesis of these fractures and identifies potential key risk factors. The majority of bones from affected first-lactation dairy cows have osteoporosis, which is associated with inadequate bone formation and increased bone resorption. In addition, low total collagen content in bones from most affected dairy cows supports the hypothesis that inadequate bone formation is an important risk factor associated with humeral fractures in these cows. Spectroscopic analyses further confirmed a significant reduction in bone quality and strength. Novel findings suggest that low liver copper concentration in many of the affected cows' results from the mobilisation of copper to the bone. Although limited, the accumulated evidence suggests that to mitigate the incidence of catastrophic fractures, adequate nutrition (especially protein-energy) should be supplied during important growth periods. While significant progress has been made in understanding the cause of these fractures, many uncertainties and areas requiring further research remain.
dc.description.confidentialfalse
dc.edition.edition2025
dc.identifier.citationWehrle-Martinez AS, Lawrence KE, Back PJ, Rogers CW, Gibson MJ, Dittmer KE. (2025). Insights into the pathogenesis of catastrophic spontaneous humeral fractures in first-lactation dairy cows. Animal Production Science. 65. 7.
dc.identifier.doi10.1071/AN24358
dc.identifier.eissn1836-5787
dc.identifier.elements-typejournal-article
dc.identifier.issn1836-0939
dc.identifier.numberAN24358
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/72935
dc.languageEnglish
dc.publisherCSIRO Publishing, Australia
dc.publisher.urihttps://www.publish.csiro.au/AN/AN24358
dc.relation.isPartOfAnimal Production Science
dc.rights(c) 2025 The Author/s
dc.rightsCC BY-NC-ND 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectbone
dc.subjectcollagen
dc.subjectcopper
dc.subjectdairy cow
dc.subjectheifer
dc.subjecthumeral fracture
dc.subjectmalnutrition
dc.subjectosteoporosis
dc.subjectprotein/energy
dc.titleInsights into the pathogenesis of catastrophic spontaneous humeral fractures in first-lactation dairy cows
dc.typeJournal article
pubs.elements-id500754
pubs.organisational-groupOther
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