B vitamins and homocysteine as determinants of bone health: A literature review of human studies
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Date
2023-06
Open Access Location
Authors
Kruger MC
Journal Title
Journal ISSN
Volume Title
Publisher
John Wiley and Sons Ltd on behalf of British Dietetic Association
Rights
CC BY 4.0
Abstract
Although there are several factors related to bone diseases such as physical activity, gender (oestrogen), race/ethnicity, smoking and alcohol habits, nutrition is a modifiable risk factor that could be employed to prevent or manage the onset of bone health diseases such as osteoporosis in humans. Aside from calcium and vitamin D, B vitamins are a group of water-soluble vitamins that play a vital role in cell metabolism. In this review, current evidence on B vitamins and bone health is assessed. Clinical trials (interventions) indicate that treatment with B vitamins impact the concentrations of total plasma/serum homocysteine concentrations (tHcy); however, most studies have reported the lack of an effect of low homocysteine concentrations on bone turnover markers, bone mineral density or fracture risks. Current studies have been inconsistent in their reports on the role of B vitamins and homocysteine in bone health. More data are therefore required to show the mechanism and effect of tHcy and B vitamins on bone mineral density, bone metabolism and fracture risk.
Description
(c) 2022 The Author/s
Keywords
B vitamins, BMD, bone health, bone metabolism, homocysteine, osteoporosis, Humans, Vitamin B Complex, Bone Density, Homocysteine, Osteoporosis, Bone and Bones, Fractures, Bone, Folic Acid, Vitamin B 12
Citation
Ilesanmi-Oyelere BL, Kruger MC. (2023). B vitamins and homocysteine as determinants of bone health: A literature review of human studies.. J Hum Nutr Diet. 36. 3. (pp. 1031-1044).