Novel viruses: Update on the significance of papillomavirus infections in cats

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dc.citation.issue5
dc.citation.volume21
dc.contributor.authorMunday JS
dc.contributor.authorSharp CR
dc.contributor.authorBeatty JA
dc.date.available2019-05
dc.date.issued2019-05
dc.description.abstractPRACTICAL RELEVANCE: Prior to 1990 papillomaviruses (PVs) were not recognised to infect or cause disease in domestic cats. Since this time, the use of histology, immunohistochemistry and, more recently, molecular techniques has revealed that PVs almost certainly cause feline viral plaques and Bowenoid in situ carcinomas, oral papillomas and feline sarcoids. In addition, there is increasing evidence that PVs play a significant role in the development of feline cutaneous squamous cell carcinomas, one of the most common skin cancers of cats. Recent studies have also revealed that most cats are asymptomatically infected with PVs. This raises a critical question that is currently unanswered: why do only a small proportion of infected cats develop disease? In the future it may be possible to prevent PV-induced diseases by using a vaccine to prevent PV infection. Alternatively, novel therapies may be developed that prevent PVs from causing clinical disease by stimulating the host immune response. CLINICAL CHALLENGES: A recognition of the skin diseases caused by PVs is important to more accurately predict disease progression. Unfortunately, there are currently no non-surgical treatments that have been proven to be beneficial in cats and clinical management of PV-induced skin disease in cats can be challenging. GLOBAL IMPORTANCE: PVs have a worldwide distribution and negatively impact feline health and welfare globally. AUDIENCE: This review is aimed at clinicians, especially those who regularly treat cats with skin disease. The review will also be useful to oncologists and researchers who have an interest in how cancer develops in cats. EVIDENCE BASE: In producing this update the authors have drawn on recently published peer-reviewed literature.
dc.description.publication-statusPublished
dc.format.extent409 - 418
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000465920600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifier.citationJOURNAL OF FELINE MEDICINE AND SURGERY, 2019, 21 (5), pp. 409 - 418
dc.identifier.doi10.1177/1098612X18808105
dc.identifier.eissn1532-2750
dc.identifier.elements-id417513
dc.identifier.harvestedMassey_Dark
dc.identifier.issn1098-612X
dc.publisherSAGE Publications on behalf of the International Society of Feline Medicine and American Association of Feline Practitioners
dc.relation.isPartOfJOURNAL OF FELINE MEDICINE AND SURGERY
dc.rightsThe Author(s). Sage Publications
dc.subjectVirus
dc.subjectpapillomavirus
dc.subjectviral plaque
dc.subjectBowenoid in situ carcinoma
dc.subjectskin cancer
dc.subject.anzsrc0707 Veterinary Sciences
dc.titleNovel viruses: Update on the significance of papillomavirus infections in cats
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Veterinary Science
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