Journal Articles
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Item Indigenous Perspectives and Gene Editing in Aotearoa New Zealand(Frontiers Media SA, 2019-04-11) Hudson M; Mead ATP; Chagné D; Roskruge N; Morrison S; Wilcox PL; Allan AC; Robienski JGene editing is arguably the most significant recent addition to the modern biotechnology toolbox, bringing both profoundly challenging and enabling opportunities. From a technical point of view the specificity and relative simplicity of these new tools has broadened the potential applications. However, from an ethical point of view it has re-ignited the debates generated by earlier forms of genetic modification. In New Zealand gene editing is currently considered genetic modification and is subject to approval processes under the Environmental Protection Authority (EPA). This process requires decision makers to take into account Māori perspectives. This article outlines previously articulated Māori perspectives on genetic modification and considers the continuing influence of those cultural and ethical arguments within the new context of gene editing. It also explores the range of ways cultural values might be used to analyse the risks and benefits of gene editing in the Aotearoa New Zealand context. Methods used to obtain these perspectives consisted of (a) review of relevant literature regarding lessons learned from the responses of Maori to genetic modification, (b) interviews of selected 'key Maori informants' and (c) surveys of self-selected individuals from groups with interests in either genetics or environmental management. The outcomes of this pilot study identified that while Māori informants were not categorically opposed to new and emerging gene editing technologies a priori, they suggest a dynamic approach to regulation is required where specific uses or types of uses are approved on a case by case basis. This study demonstrates how the cultural cues that Māori referenced in the genetic modification debate continue to be relevant in the context of gene editing but that further work is required to characterize the strength of various positions across the broader community.Item Germline CDH1 mutations are a significant contributor to the high frequency of early-onset diffuse gastric cancer cases in New Zealand Māori.(Springer Nature, 2018-03-27) Hakkaart C; Ellison-Loschmann L; Day R; Sporle A; Koea J; Harawira P; Cheng S; Gray M; Whaanga T; Pearce N; Guilford PNew Zealand Māori have a considerably higher incidence of gastric cancer compared to non-Māori, and are one of the few populations worldwide with a higher prevalence of diffuse-type disease. Pathogenic germline CDH1 mutations are causative of hereditary diffuse gastric cancer, a cancer predisposition syndrome primarily characterised by an extreme lifetime risk of developing diffuse gastric cancer. Pathogenic CDH1 mutations are well described in Māori families in New Zealand. However, the contribution of these mutations to the high incidence of gastric cancer is unknown. We have used next-generation sequencing, Sanger sequencing, and Multiplex Ligation-dependent Probe Amplification to examine germline CDH1 in an unselected series of 94 Māori gastric cancer patients and 200 healthy matched controls. Overall, 18% of all cases, 34% of cases diagnosed with diffuse-type gastric cancer, and 67% of cases diagnosed aged less than 45 years carried pathogenic CDH1 mutations. After adjusting for the effect of screening known HDGC families, we estimate that 6% of all advanced gastric cancers and 13% of all advanced diffuse-type gastric cancers would carry germline CDH1 mutations. Our results demonstrate that germline CDH1 mutations are a significant contributor to the high frequency of diffuse gastric cancer in New Zealand Māori.Item Historical translocations by Māori may explain the distribution and genetic structure of a threatened surf clam in Aotearoa (New Zealand)(Springer Nature Ltd, 2018-11-22) Ross PM; Knox MA; Smith S; Smith H; Williams J; Hogg IDThe population genetic structure of toheroa (Paphies ventricosa), an Aotearoa (New Zealand) endemic surf clam, was assessed to determine levels of inter-population connectivity and test hypotheses regarding life history, habitat distribution and connectivity in coastal vs. estuarine taxa. Ninety-eight toheroa from populations across the length of New Zealand were sequenced for the mitochondrial cytochrome c oxidase I gene with analyses suggesting a population genetic structure unique among New Zealand marine invertebrates. Toheroa genetic diversity was high in Te Ika-a Māui (the North Island of New Zealand) but completely lacking in the south of Te Waipounamu (the South Island), an indication of recent isolation. Changes in habitat availability, long distance dispersal events or translocation of toheroa to southern New Zealand by Māori could explain the observed geographic distribution of toheroa and their genetic diversity. Given that early-Māori and their ancestors, were adept at food cultivation and relocation, the toheroa translocation hypothesis is plausible and may explain the disjointed modern distribution of this species. Translocation would also explain the limited success in restoring what may in some cases be ecologically isolated populations located outside their natural distributions and preferred nichesItem Lowering hospital walls to achieve health equity(BMJ Publishing Group Ltd, 2018-09-20) Matheson A; Bourke C; Verhoeven A; Khan MI; Nkunda D; Dahar Z; Ellison-Loschmann LHospitals have evolved to become integral and dominant components of health systems, although their functions, organisation, size, degree of centralisation, and resourcing varies across countries. Despite this diversity, hospitals are generally focused on providing services for sick people rather than prevention. Although many have shown the capacity to quickly adopt new technologies, especially for diagnosing and managing illness, achieving institutional change to tackle the systemic causes of health inequities has proved much more difficult. We argue that the actions of hospitals contribute to health inequities. This is important given that hospitals hold an inordinate share of power, resources, and influence within health and community systems—while primary care and prevention are consistently undervalued and underfunded. We draw on four opportunistically selected country case examples to show the role that hospitals can play in overcoming systemic barriers to health equity. Each example highlights health sector actions taken for particular population groups: women and children in Pakistan and Rwanda and the indigenous peoples of Australia and New Zealand.Item Mild traumatic brain injury in New Zealand: factors influencing post-concussion symptom recovery time in a specialised concussion service.(CSIRO Publishing, 2018-06-28) Forrest RHJ; Henry JD; McGarry PJ; Marshall RNINTRODUCTION: By 2020, traumatic brain injuries (TBIs) are predicted to become the third largest cause of disease burden globally; 90% of these being mild traumatic brain injury (mTBI). Some patients will develop post-concussion syndrome. AIM: To determine whether the time between sustaining a mTBI and the initial assessment by a specialised concussion service, along with the post-concussion symptoms reported at the assessment, affected recovery time. METHODS: A retrospective medical record review of clients who had completed the Rivermead Post-Concussion Questionnaire (RPQ) at their initial assessment and were discharged from a large metropolitan concussion service in New Zealand was undertaken over a 6-month period in 2014 (n = 107). Using correlations, General Linear Mixed-effects Models (GLMM) and linear regressions, we explored associations between factors including ethnicity, gender and accident type, along with individual RPQ symptom scores and cluster scores, with time from injury to initial assessment by the specialised concussion service and initial assessment to discharge. RESULTS: Time from injury to initial assessment by a specialist concussion service was correlated with proportionally more psychological symptoms present at initial assessments (r = 0.222, P = 0.024); in particular, feeling depressed or tearful (r = 0.292, P = 0.003). Time to discharge was correlated with individual RPQ symptom proportions present at initial assessment for headaches (r = -0.238, P = 0.015), sensitivity to noise (r = 0.220, P = 0.026), feeling depressed or tearful (r = 0.193, P = 0.051) and feeling frustrated or impatient (r = 0.252, P = 0.003), along with the psychological cluster proportion (r = 0.235, P = 0.017) and the total RPQ score (r = 0.425, P < 0.001). CONCLUSION: Prompt diagnosis and treatment of mTBI may minimise the severity of post-concussion symptoms, especially symptoms associated with mental health and wellbeing.Item An optimisation process to motivate effective adoption of BIM for refurbishment of complex buildings in New Zealand(Higher Education Press Limited Company. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd., 2019-12) Okakpu A; GhaffarianHoseini A; Tookey J; Haar J; Ghaffarian Hoseini ADespite the multidisciplinary networks involved in refurbishment of complex building projects, the lack of BIM adoption signifies lack of real BIM benefits towards acceptance of BIM within Architecture, Engineering and Construction (AEC). To this end, this study empirically examines the potential real benefits between traditional network and BIM network for a real-time refurbishment case study project, through agent-based simulation modelling. A social network analysis theory is adapted to model the project interaction networks and a BIM prototype network. An assessment of the main stakeholders for BIM perception is carried out. We offered three prototype interaction networks for comparison of real BIM benefit. An agent-based Bayesian network model is used to simulate the propagation of design error within the project networks. The result of the analysis show that BIM project diffuses error efficiently, while stakeholders recovers faster and nearly at the same time than traditional network. The optimised network shows better performance to the traditional network, when there is early involvement of subcontractors. The main contribution of this study is providing a novel approach to compare real benefits for traditional method to BIM method for refurbishment project and to provide avenue for project stakeholders to optimise their interaction through adoption of BIM.Item Using the stars to indigenize the public sphere: Matariki over New Zealand(MDPI (Basel, Switzerland), 2019-07-16) Hardy A; Whaanga HAs the rate of affiliation to Christian identity continues to decline in Aotearoa New Zealand (only 49 percent of the population said they were Christian in the last census), public space has become more receptive to other forms of religiosity. In particular, community rituals around the winter movements of the Matariki (Pleiades) constellation have gained support since the year 2000. For instance, the capital city, Wellington, has replaced a centuries’ old British fireworks festival, Guy Fawkes, with an enlarged version of its Matariki celebrations: an action seen as a tipping point in the incorporation of Māori spiritual values into public life. Interactions between European colonisers and Māori have been characterised for more than 250 years by tensions between the relational thinking of Māori who see human beings as both participating in and constrained by an environment resonant with divine energies, and the quantitative, hierarchical, ‘Great Chain of Being’ model that had long been dominant among Europeans. Now, when the natural environment worldwide is under strain from population and economic pressures, it seems to some both appropriate and vital to look to epistemological and spiritual models that are intimately responsive to the specificities of location.Item Reduction in morbidity and mortality of dairy calves from an injectable trace mineral supplement(BMJ Group on behalf of the British Veterinary Association, 2019-06-01) Bates A; Wells M; Laven RA; Simpson MThe effect of a multimineral preparation on the health and growth of spring born, dairy calves was investigated on four New Zealand pastoral farms. Calves were randomly allocated injections within 24 hours of birth, 35 days and 70 days after birth. Injections contained 40 mg zinc, 10 mg manganese, 5 mg selenium, 15 mg copper and 5 mg chromium per ml (Multimin+Se+ Cu+Cr Cattle, Virbac South Africa) at 1 ml/50 kg body weight. Morbidity, mortality from natural challenge and growth rates were recorded for 140 days. There were no differences in morbidity and mortality within 48 hours of birth for treated calves compared with controls, P=0.192. Morbidity and mortality were highest at 3-35 days (7.5 per cent [95 per cent CI 5.00 to 9.99] treated calves sick and 15.6 per cent [95 per cent CI 12.48 to 18.73] controls sick, P<0.001). For this period, mortality was lower at 4.4 per cent (95 per cent CI 2.49 to 6.41) treated calves and 10.4 per cent (95 per cent CI 7.78 to 13.03) controls, P<0.001. Allowing for potential confounders, the adjusted OR of treated calves scouring between 3 and 35 days was 0.44 (95 per cent CI 0.24 to 0.82, P=0.009). Allowing for potential confounders, from 0 to 140 days a second model predicted treatment approximately halved the probability of morbidity and mortality (P<0.001). There was no difference in the daily rate of gain (0.67 kg/day [95 per cent CI 0.66 to 0.67] for treated calves).Item Review of the New Zealand Theileria orientalis Ikeda Type Epidemic and Epidemiological Research since 2012.(19/10/2021) Lawrence K; Gedye K; McFadden A; Pulford D; Heath A; Pomroy WThis article sets out to document and summarise the New Zealand epidemic and the epidemiological research conducted on the epizootic of bovine anaemia associated with Theileria orientalis Ikeda type infection, which began in New Zealand in August 2012. As New Zealand has no other pathogenic tick-borne cattle haemoparasites, the effects of the T. orientalis Ikeda type infection observed in affected herds and individual animals were not confounded by other concurrent haemoparasite infections, as was possibly the case in other countries. This has resulted in an unbiased perspective of a new disease. In addition, as both New Zealand's beef and dairy cattle systems are seasonally based, this has led to a different epidemiological presentation than that reported by almost all other affected countries. Having verified the establishment of a new disease and identified the associated pathogen, the remaining key requirements of an epidemiological investigation, for a disease affecting production animals, are to describe how the disease spreads, describe the likely impacts of that disease at the individual and herd level and explore methods of disease control or mitigation.Item Pacific Accounting Review – The First Twenty-Five Years(Emerald Group Publishing Limited, 2013) Bradbury, Michael E; Hooks, JillPurpose – In 2012, Pacific Accounting Review (PAR) completed its 25th year of existence. This paper aims to review all articles published in PAR as a report on the “stewardship” of the journal. Design/methodology/approach – Research papers published in PAR are analysed by topic, research methodology, author and institutional affiliation. This approach follows prior reviews in PAR. A comparison is also made with PAR over the period 1988-1996 and Accounting and Finance over the period 1973-1999 and the “top accounting journals” over the period 1990-2007. Findings – The analysis indicates that PAR publishes papers across a wide range of topics, but uses research methodologies that are consistent with mainstream accounting research (as undertaken by the “top accounting journals”). The authors of PAR are concentrated in New Zealand and Australia, as is the source data. No strong trends were perceived in the data. In conclusion, PAR can be characterised as a broadly based accounting and finance journal that is primarily competing in an Australasian context. Practical implications – This review provides some insight as to how the journal has evolved and how the mission statement has been put into effect. The journal has maintained much of its original mission. The anticipated “dialogue between researchers and practitioners” has not developed, probably due to lack of sponsorship by the profession. The paper should also form a basis for informing how to further develop the journal. Originality/value – The paper updates the last review of PAR which was completed in 1997.