Population Structure and Antimicrobial Resistance in Campylobacter jejuni and C. coli Isolated from Humans with Diarrhea and from Poultry, East Africa.
Loading...
Date
2024-10
Open Access Location
Journal Title
Journal ISSN
Volume Title
Publisher
Centers for Disease Control and Prevention
Rights
(c) The author/s
CC BY 4.0
CC BY 4.0
Abstract
Campylobacteriosis and antimicrobial resistance (AMR) are global public health concerns. Africa is estimated to have the world's highest incidence of campylobacteriosis and a relatively high prevalence of AMR in Campylobacter spp. from humans and animals. Few studies have compared Campylobacter spp. isolated from humans and poultry in Africa using whole-genome sequencing and antimicrobial susceptibility testing. We explored the population structure and AMR of 178 Campylobacter isolates from East Africa, 81 from patients with diarrhea in Kenya and 97 from 56 poultry samples in Tanzania, collected during 2006-2017. Sequence type diversity was high in both poultry and human isolates, with some sequence types in common. The estimated prevalence of multidrug resistance, defined as resistance to >3 antimicrobial classes, was higher in poultry isolates (40.9%, 95% credible interval 23.6%-59.4%) than in human isolates (2.5%, 95% credible interval 0.3%-6.8%), underlining the importance of antimicrobial stewardship in livestock systems.
Description
Keywords
Campylobacter coli, Campylobacter jejuni, Kenya, Tanzania, antimicrobial resistance, bacteria, campylobacteriosis, east Africa, enteric infections, humans, poultry, zoonoses, Humans, Campylobacter jejuni, Animals, Diarrhea, Campylobacter Infections, Poultry, Anti-Bacterial Agents, Campylobacter coli, Microbial Sensitivity Tests, Drug Resistance, Bacterial, Poultry Diseases, Whole Genome Sequencing, Africa, Eastern, Drug Resistance, Multiple, Bacterial, Phylogeny
Citation
French NP, Thomas KM, Amani NB, Benschop J, Bigogo GM, Cleaveland S, Fayaz A, Hugho EA, Karimuribo ED, Kasagama E, Maganga R, Melubo ML, Midwinter AC, Mmbaga BT, Mosha VV, Mshana FI, Munyua P, Ochieng JB, Rogers L, Sindiyo E, Swai ES, Verani JR, Widdowson M-A, Wilkinson DA, Kazwala RR, Crump JA, Zadoks RN. (2024). Population Structure and Antimicrobial Resistance in Campylobacter jejuni and C. coli Isolated from Humans with Diarrhea and from Poultry, East Africa.. Emerg Infect Dis. 30. 10. (pp. 2079-2089).